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HAT1

CANCER ATLAS

Gene description

 Histone acetyltransferase 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036788
CAB037191

GENE INFORMATION

Gene name

 HAT1 (HGNC Symbol)

Synonyms

 KAT1

Description

 Histone acetyltransferase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 171922448 - 171983682

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128708 (version 83.38)

Entrez gene

 8520

UniProt

 O14929 (UniProt - Evidence at protein level)

neXtProt

 NX_O14929

Antibodypedia

 HAT1 antibodies

PROTEIN BROWSER
HAT1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAT1-001
ENSP00000264108
ENST00000264108
O14929 [Direct mapping]
Histone acetyltransferase type B catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000790 [nuclear chromatin]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006348 [chromatin silencing at telomere]
GO:0006475 [internal protein amino acid acetylation]
GO:0007584 [response to nutrient]
GO:0010485 [H4 histone acetyltransferase activity]
GO:0016363 [nuclear matrix]
GO:0016568 [chromatin modification]
GO:0016573 [histone acetylation]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
Show all
 419 aa
49.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.