Tissue expression of HOXD10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HOXD10
Gene description	Homeobox D10
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (endometrium, smooth muscle)
GTEx:	Group enriched (endometrium, vagina, prostate, cervix, uterine, kidney, colon)
FANTOM5:	Tissue enhanced (endometrium, kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium, smooth muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (endometrium, vagina, prostate, cervix, uterine, kidney, colon)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium, kidney)

GENE INFORMATION
Gene name	HOXD10 (HGNC Symbol)
Synonyms	HOX4, HOX4D
Description	Homeobox D10 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as ""rocker-bottom foot"" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	176108790 - 176119942
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128710 (version 83.38)
Entrez gene	3236
UniProt	P28358 (UniProt - Evidence at protein level)
neXtProt	NX_P28358
Antibodypedia	HOXD10 antibodies

PROTEIN BROWSER

HOXD10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXD10-001 ENSP00000249501 ENST00000249501	P28358 [Direct mapping] Homeobox protein Hox-D10 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0001501 [skeletal system development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007338 [single fertilization] GO:0007519 [skeletal muscle tissue development] GO:0008344 [adult locomotory behavior] GO:0009952 [anterior/posterior pattern specification] GO:0009954 [proximal/distal pattern formation] GO:0010468 [regulation of gene expression] GO:0021520 [spinal cord motor neuron cell fate specification] GO:0030326 [embryonic limb morphogenesis] GO:0035136 [forelimb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048935 [peripheral nervous system neuron development] GO:0050905 [neuromuscular process] Show all	340 aa 38.4 kDa	No	0