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HERC2

GENERAL INFORMATION

Gene name

 HERC2

Gene description

 HECT and RLD domain containing E3 ubiquitin protein ligase 2

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA048389 , CAB017188
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HERC2 (HGNC Symbol)

Synonyms

 D15F37S1, jdf2, p528

Description

 HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Chromosome

 15

Cytoband

 q13.1

Chromosome location (bp)

 28111040 - 28322152

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128731 (version 83.38)

Entrez gene

 8924

UniProt

 O95714 (UniProt - Evidence at protein level)

neXtProt

 NX_O95714

Antibodypedia

 HERC2 antibodies

PROTEIN BROWSER
HERC2-001
HERC2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HERC2-001
ENSP00000261609
ENST00000261609
O95714 [Direct mapping]
E3 ubiquitin-protein ligase HERC2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005743 [mitochondrial inner membrane]
GO:0005814 [centriole]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006886 [intracellular protein transport]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 4834 aa
527.2 kDa 		No 1
HERC2-011
ENSP00000457745
ENST00000569772
H3BUQ1 [Direct mapping]
E3 ubiquitin-protein ligase HERC2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 200 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.