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SNRPN

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GENERAL INFORMATION

Gene name

 SNRPN

Gene description

 Small nuclear ribonucleoprotein polypeptide N

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA067842
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA067842 CACO-2 Nucleoplasm
HPA067842 HEK 293 Nucleoplasm
HPA067842 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 SNRPN (HGNC Symbol)

Synonyms

 HCERN3, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN

Description

 Small nuclear ribonucleoprotein polypeptide N (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q11.2

Chromosome location (bp)

 24823637 - 24978723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128739 (version 83.38)

Entrez gene

 6638

UniProt

 P63162 (UniProt - Evidence at protein level)

neXtProt

 NX_P63162

Antibodypedia

 SNRPN antibodies

PROTEIN BROWSER
SNRPN-001
SNRPN-002
SNRPN-003
SNRPN-004
SNRPN-006
SNRPN-007
SNRPN-008
SNRPN-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNRPN-001
ENSP00000375105
ENST00000390687
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
X5DP00 [Target identity:100%; Query identity:100%]
HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 240 aa
24.6 kDa 		No 0
SNRPN-002
ENSP00000452342
ENST00000554227
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 244 aa
25.1 kDa 		No 0
SNRPN-003
ENSP00000382972
ENST00000400100
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
X5DP00 [Target identity:100%; Query identity:100%]
HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0009725 [response to hormone]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 240 aa
24.6 kDa 		No 0
SNRPN-004
ENSP00000382969
ENST00000400097
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
X5DP00 [Target identity:100%; Query identity:100%]
HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 240 aa
24.6 kDa 		No 0
SNRPN-006
ENSP00000463510
ENST00000579070
J3QLE5 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
Show all
Predicted intracellular proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 169 aa
17.5 kDa 		No 0
SNRPN-007
ENSP00000306223
ENST00000346403
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
X5DP00 [Target identity:100%; Query identity:100%]
HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 240 aa
24.6 kDa 		No 0
SNRPN-008
ENSP00000463458
ENST00000577565
P63162 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
X5DP00 [Target identity:100%; Query identity:100%]
HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 240 aa
24.6 kDa 		No 0
SNRPN-009
ENSP00000462211
ENST00000584968
J3KRY3 [Direct mapping]
Small nuclear ribonucleoprotein-associated protein N
Show all
Predicted intracellular proteins
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005737 [cytoplasm]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 59 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.