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This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Enzymes ENZYME proteins Transferases Kinases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005844 [polysome] GO:0006446 [regulation of translational initiation] GO:0006468 [protein phosphorylation] GO:0009267 [cellular response to starvation] GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation] GO:0017148 [negative regulation of translation] GO:0022626 [cytosolic ribosome] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034198 [cellular response to amino acid starvation] GO:0042803 [protein homodimerization activity] GO:0043558 [regulation of translational initiation in response to stress] GO:0045665 [negative regulation of neuron differentiation] GO:1990138 [neuron projection extension] GO:1990253 [cellular response to leucine starvation]
Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
