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TTBK2

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GENERAL INFORMATION

Gene name

 TTBK2

Gene description

 Tau tubulin kinase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Intermediate filaments (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA049866
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Intermediate filaments (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049866 CACO-2 Intermediate filaments
HPA049866 MCF7 Intermediate filaments
HPA049866 U-2 OS Intermediate filaments

GENE INFORMATION

Gene name

 TTBK2 (HGNC Symbol)

Synonyms

 KIAA0847, SCA11

Description

 Tau tubulin kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Chromosome

 15

Cytoband

 q15.2

Chromosome location (bp)

 42738734 - 42920809

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128881 (version 83.38)

Entrez gene

 146057

UniProt

 Q6IQ55 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IQ55

Antibodypedia

 TTBK2 antibodies

PROTEIN BROWSER
TTBK2-001
TTBK2-002
TTBK2-003
TTBK2-006
TTBK2-007
TTBK2-008
TTBK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TTBK2-001
ENSP00000267890
ENST00000267890
Q6IQ55 [Direct mapping]
Tau-tubulin kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007224 [smoothened signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035869 [ciliary transition zone]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
Show all
 1244 aa
137.4 kDa 		No 0
TTBK2-002
ENSP00000455734
ENST00000567840
Q6IQ55 [Direct mapping]
Tau-tubulin kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007224 [smoothened signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035869 [ciliary transition zone]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
Show all
 478 aa
54 kDa 		No 0
TTBK2-003
ENSP00000457489
ENST00000567274
A0A0B4J292 [Direct mapping]
Tau-tubulin kinase 2
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Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008360 [regulation of cell shape]
Show all
 443 aa
50.1 kDa 		No 0
TTBK2-006
ENSP00000457385
ENST00000562880
H3BTY5 [Direct mapping]
Tau-tubulin kinase 2
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Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008360 [regulation of cell shape]
Show all
 143 aa
16.1 kDa 		No 0
TTBK2-007
ENSP00000455574
ENST00000564431
H3BQ25 [Direct mapping]
Tau-tubulin kinase 2
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Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0008360 [regulation of cell shape]
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 117 aa
12.8 kDa 		No 0
TTBK2-008
ENSP00000454605
ENST00000566931
H3BMY7 [Direct mapping]
Tau-tubulin kinase 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0008360 [regulation of cell shape]
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 84 aa
9.2 kDa 		No 0
TTBK2-201
ENSP00000479984
ENST00000622375
Q8IWY7 [Direct mapping]
Tau-tubulin kinase; Tau-tubulin kinase 2
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Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005198 [structural molecule activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0006468 [protein phosphorylation]
GO:0008360 [regulation of cell shape]
GO:0045095 [keratin filament]
Show all
 1649 aa
182.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.