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ALDH1A2

CANCER ATLAS

Gene description

 Aldehyde dehydrogenase 1 family, member A2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010022

GENE INFORMATION

Gene name

 ALDH1A2 (HGNC Symbol)

Synonyms

 RALDH2

Description

 Aldehyde dehydrogenase 1 family, member A2 (HGNC Symbol)

Entrez gene summary

 This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 57953424 - 58497866

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128918 (version 83.38)

Entrez gene

 8854

UniProt

 O94788 (UniProt - Evidence at protein level)

neXtProt

 NX_O94788

Antibodypedia

 ALDH1A2 antibodies

PROTEIN BROWSER
ALDH1A2-001
ALDH1A2-002
ALDH1A2-003
ALDH1A2-016
ALDH1A2-017
ALDH1A2-021
ALDH1A2-024
ALDH1A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1A2-001
ENSP00000249750
ENST00000249750
O94788 [Direct mapping]
Retinal dehydrogenase 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001568 [blood vessel development]
GO:0001758 [retinal dehydrogenase activity]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001936 [regulation of endothelial cell proliferation]
GO:0002138 [retinoic acid biosynthetic process]
GO:0003007 [heart morphogenesis]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0007494 [midgut development]
GO:0008152 [metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009855 [determination of bilateral symmetry]
GO:0009952 [anterior/posterior pattern specification]
GO:0009954 [proximal/distal pattern formation]
GO:0010628 [positive regulation of gene expression]
GO:0014032 [neural crest cell development]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016491 [oxidoreductase activity]
GO:0016918 [retinal binding]
GO:0021915 [neural tube development]
GO:0021983 [pituitary gland development]
GO:0030182 [neuron differentiation]
GO:0030324 [lung development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030900 [forebrain development]
GO:0030902 [hindbrain development]
GO:0031016 [pancreas development]
GO:0031076 [embryonic camera-type eye development]
GO:0032355 [response to estradiol]
GO:0033189 [response to vitamin A]
GO:0034097 [response to cytokine]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035799 [ureter maturation]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048566 [embryonic digestive tract development]
GO:0048738 [cardiac muscle tissue development]
GO:0055114 [oxidation-reduction process]
GO:0060324 [face development]
GO:0071300 [cellular response to retinoic acid]
Show all
 518 aa
56.7 kDa 		No 0
ALDH1A2-002
ENSP00000309623
ENST00000347587
O94788 [Direct mapping]
Retinal dehydrogenase 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016918 [retinal binding]
GO:0021915 [neural tube development]
GO:0034097 [response to cytokine]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 480 aa
53.1 kDa 		No 0
ALDH1A2-003
ENSP00000453292
ENST00000558239
Q9UED3 [Direct mapping]
RALDH2-T; Retinal dehydrogenase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0055114 [oxidation-reduction process]
Show all
 25 aa
2.8 kDa 		No 0
ALDH1A2-016
ENSP00000453600
ENST00000558231
H0YMG7 [Direct mapping]
Retinal dehydrogenase 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 489 aa
53.8 kDa 		No 0
ALDH1A2-017
ENSP00000453408
ENST00000559517
O94788 [Direct mapping]
Retinal dehydrogenase 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016918 [retinal binding]
GO:0021915 [neural tube development]
GO:0034097 [response to cytokine]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 422 aa
46.1 kDa 		No 0
ALDH1A2-021
ENSP00000452850
ENST00000561070
H0YKL3 [Direct mapping]
Retinal dehydrogenase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 85 aa
9.6 kDa 		No 0
ALDH1A2-024
ENSP00000454028
ENST00000557967
A0A0G2JL97 [Direct mapping]
Retinal dehydrogenase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0055114 [oxidation-reduction process]
Show all
 9 aa
1 kDa 		No 0
ALDH1A2-201
ENSP00000438296
ENST00000537372
O94788 [Direct mapping]
Retinal dehydrogenase 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016918 [retinal binding]
GO:0021915 [neural tube development]
GO:0034097 [response to cytokine]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 497 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.