Cell atlas - IVD - The Human Protein Atlas

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IVD

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IVD
Gene description	Isovaleryl-CoA dehydrogenase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA041391
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (validated)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041391	A-431	Mitochondria
	HPA041391	U-2 OS	Nucleoplasm
	HPA041391	U-2 OS	Mitochondria
	HPA041391	U-251 MG	Nucleoplasm
	HPA041391	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	IVD (HGNC Symbol)
Synonyms	ACAD2
Description	Isovaleryl-CoA dehydrogenase (HGNC Symbol)
Entrez gene summary	Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40405795 - 40435947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128928 (version 83.38)
Entrez gene	3712
UniProt	P26440 (UniProt - Evidence at protein level)
neXtProt	NX_P26440
Antibodypedia	IVD antibodies

PROTEIN BROWSER

IVD-001	IVD-002	IVD-004	IVD-006	IVD-008	IVD-009	IVD-012	IVD-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IVD-001 ENSP00000418397 ENST00000487418	A0A0A0MT83 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008470 [isovaleryl-CoA dehydrogenase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0031966 [mitochondrial membrane] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	426 aa 46.7 kDa	No	0
IVD-002 ENSP00000417990 ENST00000479013	P26440 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006552 [leucine catabolic process] GO:0008152 [metabolic process] GO:0008470 [isovaleryl-CoA dehydrogenase activity] GO:0009055 [electron carrier activity] GO:0009083 [branched-chain amino acid catabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] Show all	396 aa 43.1 kDa	No	0
IVD-004 ENSP00000479359 ENST00000610693	A0A087WVD3 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	214 aa 23.3 kDa	No	0
IVD-006 ENSP00000417256 ENST00000473112	H7C4G6 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	307 aa 32.8 kDa	No	0
IVD-008 ENSP00000454145 ENST00000466756	H0YNT5 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.2 kDa	No	0
IVD-009 ENSP00000453146 ENST00000491554	H0YLC3 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	243 aa 26.4 kDa	No	0
IVD-012 ENSP00000453929 ENST00000559575	H0YNA4 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.1 kDa	No	0
IVD-013 ENSP00000453821 ENST00000558610	H0YN10 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	212 aa 23.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.