Expression of CHAC1 in cancer - Summary

CANCER ATLAS

Gene description

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Thyroid cancer

STAINING SUMMARY

HPA042708	HPA043505

GENE INFORMATION
Gene name	CHAC1 (HGNC Symbol)
Synonyms	MGC4504
Description	ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40952962 - 40956519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128965 (version 83.38)
Entrez gene	79094
UniProt	Q9BUX1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUX1
Antibodypedia	CHAC1 antibodies

PROTEIN BROWSER

CHAC1-001	CHAC1-002	CHAC1-003	CHAC1-004	CHAC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHAC1-001 ENSP00000398105 ENST00000446533	Q9BUX1 [Direct mapping] Glutathione-specific gamma-glutamylcyclotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006986 [response to unfolded protein] GO:0007219 [Notch signaling pathway] GO:0008152 [metabolic process] GO:0010955 [negative regulation of protein processing] GO:0016746 [transferase activity, transferring acyl groups] GO:0022008 [neurogenesis] GO:0045746 [negative regulation of Notch signaling pathway] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	264 aa 28.7 kDa	No	0
CHAC1-002 ENSP00000452707 ENST00000487220	H0YK90 [Direct mapping] Glutathione-specific gamma-glutamylcyclotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 3.9 kDa	No	0
CHAC1-003 ENSP00000395466 ENST00000444189	Q9BUX1 [Direct mapping] Glutathione-specific gamma-glutamylcyclotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006986 [response to unfolded protein] GO:0007219 [Notch signaling pathway] GO:0008152 [metabolic process] GO:0010955 [negative regulation of protein processing] GO:0016746 [transferase activity, transferring acyl groups] GO:0022008 [neurogenesis] GO:0045746 [negative regulation of Notch signaling pathway] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	219 aa 23.8 kDa	No	0
CHAC1-004 ENSP00000481816 ENST00000617961	A0A0C4DGX1 [Direct mapping] Glutathione-specific gamma-glutamylcyclotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		222 aa 24.4 kDa	No	0
CHAC1-201 ENSP00000484644 ENST00000617768	Q9BUX1 [Direct mapping] Glutathione-specific gamma-glutamylcyclotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006986 [response to unfolded protein] GO:0007219 [Notch signaling pathway] GO:0008152 [metabolic process] GO:0010955 [negative regulation of protein processing] GO:0016746 [transferase activity, transferring acyl groups] GO:0022008 [neurogenesis] GO:0045746 [negative regulation of Notch signaling pathway] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	264 aa 28.7 kDa	No	0