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KCNC1

CANCER ATLAS

Gene description

 Potassium channel, voltage gated Shaw related subfamily C, member 1

Protein class

 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047634

GENE INFORMATION

Gene name

 KCNC1 (HGNC Symbol)

Synonyms

 Kv3.1

Description

 Potassium channel, voltage gated Shaw related subfamily C, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both ""b"" and ""alpha"", while the shorter isoform has been called both ""a"" and ""beta"" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 17734812 - 17783055

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129159 (version 83.38)

Entrez gene

 3746

UniProt

 P48547 (UniProt - Evidence at protein level)

neXtProt

 NX_P48547

Antibodypedia

 KCNC1 antibodies

PROTEIN BROWSER
KCNC1-001
KCNC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNC1-001
ENSP00000368785
ENST00000379472
P48547 [Direct mapping]
Potassium voltage-gated channel subfamily C member 1
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032809 [neuronal cell body membrane]
GO:0051260 [protein homooligomerization]
GO:0051262 [protein tetramerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 511 aa
57.9 kDa 		No 6
KCNC1-002
ENSP00000265969
ENST00000265969
P48547 [Direct mapping]
Potassium voltage-gated channel subfamily C member 1
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007420 [brain development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009636 [response to toxic substance]
GO:0009642 [response to light intensity]
GO:0009986 [cell surface]
GO:0010996 [response to auditory stimulus]
GO:0014075 [response to amine]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019894 [kinesin binding]
GO:0021549 [cerebellum development]
GO:0021759 [globus pallidus development]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0032589 [neuron projection membrane]
GO:0032590 [dendrite membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0034767 [positive regulation of ion transmembrane transport]
GO:0035690 [cellular response to drug]
GO:0035864 [response to potassium ion]
GO:0043025 [neuronal cell body]
GO:0044325 [ion channel binding]
GO:0051260 [protein homooligomerization]
GO:0051262 [protein tetramerization]
GO:0055085 [transmembrane transport]
GO:0071774 [response to fibroblast growth factor]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1990089 [response to nerve growth factor]
Show all
 585 aa
65.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.