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RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
GENE INFORMATION
Gene name
CSRP3 (HGNC Symbol)
Synonyms
CLP, CMD1M, MLP
Description
Cysteine and glycine-rich protein 3 (cardiac LIM protein) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
P50461 [Direct mapping] Cysteine and glycine-rich protein 3 A2TDB8 [Target identity:100%; Query identity:100%] Cysteine and glycine-rich protein 3 (Cardiac LIM protein); Cysteine and glycine-rich protein 3 (Cardiac LIM protein), isoform CRA_a; cDNA, FLJ93801, Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIMprotein) (CSRP3), mRNA
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Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001974 [blood vessel remodeling] GO:0002026 [regulation of the force of heart contraction] GO:0003300 [cardiac muscle hypertrophy] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006874 [cellular calcium ion homeostasis] GO:0007519 [skeletal muscle tissue development] GO:0008270 [zinc ion binding] GO:0008307 [structural constituent of muscle] GO:0030018 [Z disc] GO:0031433 [telethonin binding] GO:0033365 [protein localization to organelle] GO:0035995 [detection of muscle stretch] GO:0042805 [actinin binding] GO:0045662 [negative regulation of myoblast differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048738 [cardiac muscle tissue development] GO:0055003 [cardiac myofibril assembly] GO:0060048 [cardiac muscle contraction] GO:1903919 [negative regulation of actin filament severing] GO:1903920 [positive regulation of actin filament severing]
P50461 [Direct mapping] Cysteine and glycine-rich protein 3 A2TDB8 [Target identity:100%; Query identity:100%] Cysteine and glycine-rich protein 3 (Cardiac LIM protein); Cysteine and glycine-rich protein 3 (Cardiac LIM protein), isoform CRA_a; cDNA, FLJ93801, Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIMprotein) (CSRP3), mRNA
Show all
Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction] GO:0003300 [cardiac muscle hypertrophy] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0006874 [cellular calcium ion homeostasis] GO:0007519 [skeletal muscle tissue development] GO:0008270 [zinc ion binding] GO:0008307 [structural constituent of muscle] GO:0030018 [Z disc] GO:0031433 [telethonin binding] GO:0033365 [protein localization to organelle] GO:0035995 [detection of muscle stretch] GO:0042805 [actinin binding] GO:0045662 [negative regulation of myoblast differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048738 [cardiac muscle tissue development] GO:0055003 [cardiac myofibril assembly] GO:0060048 [cardiac muscle contraction] GO:1903919 [negative regulation of actin filament severing] GO:1903920 [positive regulation of actin filament severing]
