Expression of MPDU1 in cancer - Summary

CANCER ATLAS

Gene description

Mannose-P-dolichol utilization defect 1

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014845

GENE INFORMATION
Gene name	MPDU1 (HGNC Symbol)
Synonyms	CDGIf, Lec35, PQLC5, SL15
Description	Mannose-P-dolichol utilization defect 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum membrane protein that is required for utilization of the mannose donor mannose-P-dolichol in the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositols. Mutations in this gene result in congenital disorder of glycosylation type If. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7583529 - 7592789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129255 (version 83.38)
Entrez gene	9526
UniProt	O75352 (UniProt - Evidence at protein level)
neXtProt	NX_O75352
Antibodypedia	MPDU1 antibodies

PROTEIN BROWSER

MPDU1-001	MPDU1-006	MPDU1-022	MPDU1-024	MPDU1-025	MPDU1-026	MPDU1-028	MPDU1-029	MPDU1-201	MPDU1-202	MPDU1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPDU1-001 ENSP00000250124 ENST00000250124	O75352 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006810 [transport] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	247 aa 26.6 kDa	No	7
MPDU1-006 ENSP00000414071 ENST00000423172	O75352 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006810 [transport] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	186 aa 19.8 kDa	No	2
MPDU1-022 ENSP00000379758 ENST00000396501	J3QW43 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	192 aa 20.9 kDa	No	3
MPDU1-024 ENSP00000462839 ENST00000584378	J3KT75 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	154 aa 16.5 kDa	No	2
MPDU1-025 ENSP00000463037 ENST00000585217	J3KTK8 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	116 aa 12.7 kDa	No	3
MPDU1-026 ENSP00000464158 ENST00000579445	J3QRD5 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	194 aa 20.8 kDa	No	5
MPDU1-028 ENSP00000463966 ENST00000581380	J3QQZ4 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	152 aa 16.7 kDa	No	3
MPDU1-029 ENSP00000462500 ENST00000582151	J3KSI4 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.8 kDa	No	0
MPDU1-201 ENSP00000483943 ENST00000614740	Q1HDL3 [Direct mapping] HBeAg-binding protein 2 binding protein A; Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	299 aa 32 kDa	No	4
MPDU1-202 ENSP00000483915 ENST00000620608	Q9H3L2 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein; My008 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	211 aa 22.6 kDa	No	4
MPDU1-203 ENSP00000479257 ENST00000621041	A0A087WV81 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	299 aa 32 kDa	No	4