We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008024 [positive transcription elongation factor complex b] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0017069 [snRNA binding] GO:0019901 [protein kinase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050434 [positive regulation of viral transcription] GO:0051301 [cell division] GO:1900364 [negative regulation of mRNA polyadenylation] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
