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AP1M2

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GENERAL INFORMATION

Gene name

 AP1M2

Gene description

 Adaptor-related protein complex 1, mu 2 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (Hep G2, MCF7, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA054999
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, MCF7, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA054999 A-431 Vesicles
HPA054999 CACO-2 Vesicles
HPA054999 U-2 OS Vesicles

GENE INFORMATION

Gene name

 AP1M2 (HGNC Symbol)

Synonyms

 AP1-mu2, HSMU1B, mu2

Description

 Adaptor-related protein complex 1, mu 2 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10572671 - 10587315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129354 (version 83.38)

Entrez gene

 10053

UniProt

 Q9Y6Q5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6Q5

Antibodypedia

 AP1M2 antibodies

PROTEIN BROWSER
AP1M2-001
AP1M2-002
AP1M2-003
AP1M2-006
AP1M2-007
AP1M2-008
AP1M2-009
AP1M2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1M2-001
ENSP00000465685
ENST00000590923
Q9Y6Q5 [Direct mapping]
AP-1 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006605 [protein targeting]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006903 [vesicle targeting]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
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 425 aa
48.2 kDa 		No 0
AP1M2-002
ENSP00000250244
ENST00000250244
Q9Y6Q5 [Direct mapping]
AP-1 complex subunit mu-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006605 [protein targeting]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006903 [vesicle targeting]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 423 aa
48.1 kDa 		No 0
AP1M2-003
ENSP00000466494
ENST00000591676
K7EMG5 [Direct mapping]
AP-1 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
GO:0043231 [intracellular membrane-bounded organelle]
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 299 aa
33.3 kDa 		No 0
AP1M2-006
ENSP00000467498
ENST00000589684
K7EPR4 [Direct mapping]
AP-1 complex subunit mu-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 239 aa
27.4 kDa 		No 0
AP1M2-007
ENSP00000468260
ENST00000592285
K7ERH5 [Direct mapping]
AP-1 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 103 aa
11.5 kDa 		No 0
AP1M2-008
ENSP00000465865
ENST00000587069
K7EL08 [Direct mapping]
AP-1 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 128 aa
14.6 kDa 		No 0
AP1M2-009
ENSP00000465488
ENST00000589348
K7EK69 [Direct mapping]
AP-1 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
5.1 kDa 		No 0
AP1M2-010
ENSP00000465193
ENST00000591240
K7EJJ1 [Direct mapping]
AP-1 complex subunit mu-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 245 aa
27.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.