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SNX6

CANCER ATLAS

Gene description

 Sorting nexin 6

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049374

GENE INFORMATION

Gene name

 SNX6

Synonyms

Description

 Sorting nexin 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q13.1

Chromosome location (bp)

 34561094 - 34630183

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129515 (version 83.38)

Entrez gene

 58533

UniProt

 Q9UNH7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNH7

Antibodypedia

 SNX6 antibodies

PROTEIN BROWSER
SNX6-001
SNX6-002
SNX6-005
SNX6-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX6-001
ENSP00000379779
ENST00000396526
Q9UNH7 [Direct mapping]
Sorting nexin-6 Sorting nexin-6, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031901 [early endosome membrane]
GO:0034452 [dynactin binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0097422 [tubular endosome]
Show all
 290 aa
33.6 kDa 		No 0
SNX6-002
ENSP00000355217
ENST00000362031
A0A0A0MRI2 [Direct mapping]
Sorting nexin 6, isoform CRA_b; Sorting nexin-6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035091 [phosphatidylinositol binding]
Show all
 418 aa
47.8 kDa 		No 0
SNX6-005
ENSP00000452577
ENST00000557265
G3V5X9 [Direct mapping]
Sorting nexin-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 239 aa
27 kDa 		No 0
SNX6-009
ENSP00000452520
ENST00000555648
G3V5U2 [Direct mapping]
Sorting nexin-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0035091 [phosphatidylinositol binding]
Show all
 132 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.