Expression of RNASE1 in cancer - Summary

CANCER ATLAS

Gene description

Ribonuclease, RNase A family, 1 (pancreatic)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001140

GENE INFORMATION
Gene name	RNASE1 (HGNC Symbol)
Synonyms	RAC1, RNS1
Description	Ribonuclease, RNase A family, 1 (pancreatic) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20801228 - 20803278
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129538 (version 83.38)
Entrez gene	6035
UniProt	P07998 (UniProt - Evidence at protein level)
neXtProt	NX_P07998
Antibodypedia	RNASE1 antibodies

PROTEIN BROWSER

RNASE1-001	RNASE1-002	RNASE1-003	RNASE1-004	RNASE1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASE1-001 ENSP00000381057 ENST00000397967	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-002 ENSP00000344193 ENST00000340900	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-003 ENSP00000381060 ENST00000397970	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-004 ENSP00000399493 ENST00000412779	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-005 ENSP00000451058 ENST00000555698	G3V357 [Direct mapping] Ribonuclease pancreatic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	116 aa 13 kDa	No	0