Cell atlas - NEDD8 - The Human Protein Atlas

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NEDD8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NEDD8
Gene description	Neural precursor cell expressed, developmentally down-regulated 8
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB004082
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB004082	A-431	Nucleoplasm	Intensity
	CAB004082	A-431	Cytosol
	CAB004082	U-2 OS	Nucleoplasm	Intensity
	CAB004082	U-2 OS	Cytosol
	CAB004082	U-251 MG	Nucleoplasm	Intensity
	CAB004082	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NEDD8 (HGNC Symbol)
Synonyms	Nedd-8
Description	Neural precursor cell expressed, developmentally down-regulated 8 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24216852 - 24232454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129559 (version 83.38)
Entrez gene	4738
UniProt	Q15843 (UniProt - Evidence at protein level)
neXtProt	NX_Q15843
Antibodypedia	NEDD8 antibodies

PROTEIN BROWSER

NEDD8-001	NEDD8-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEDD8-001 ENSP00000250495 ENST00000250495	Q15843 [Direct mapping] NEDD8 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006508 [proteolysis] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008104 [protein localization] GO:0009653 [anatomical structure morphogenesis] GO:0014070 [response to organic cyclic compound] GO:0031625 [ubiquitin protein ligase binding] GO:0045116 [protein neddylation] GO:0070062 [extracellular exosome] Show all	81 aa 9.1 kDa	No	0
NEDD8-004 ENSP00000448192 ENST00000524927	F8VSA6 [Direct mapping] NEDD8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	50 aa 5.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.