Expression of DAD1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Defender against cell death 1

Protein class

Cancer-related genes, Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028882

GENE INFORMATION
Gene name	DAD1 (HGNC Symbol)
Synonyms	OST2
Description	Defender against cell death 1 (HGNC Symbol)
Entrez gene summary	DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	22564905 - 22589269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129562 (version 83.38)
Entrez gene	1603
UniProt	P61803 (UniProt - Evidence at protein level)
neXtProt	NX_P61803
Antibodypedia	DAD1 antibodies

PROTEIN BROWSER

DAD1-002	DAD1-004	DAD1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAD1-002 ENSP00000250498 ENST00000250498	P61803 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001824 [blastocyst development] GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006915 [apoptotic process] GO:0007584 [response to nutrient] GO:0008250 [oligosaccharyltransferase complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	113 aa 12.5 kDa	No	3
DAD1-004 ENSP00000440242 ENST00000538631	A0A0B4J239 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0006486 [protein glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	78 aa 8.5 kDa	No	2
DAD1-005 ENSP00000440821 ENST00000543337	F5GXX5 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0006486 [protein glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	85 aa 9.6 kDa	No	2