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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SEC14L1
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

SEC14-like lipid binding 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021463
HPA028703

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells displayed weak to moderate cytoplasmic and/or nuclear positivity. Strong staining was observed in a few urothelial and renal cancers.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed moderate to strong granular cytoplasmic staining and slightly weaker nuclear positivity. Several cases of lymphomas and renal cancers displayed weak staining or were negative.

GENE INFORMATION

Gene name

SEC14L1 (HGNC Symbol)

Synonyms

PRELID4A, SEC14L

Description

SEC14-like lipid binding 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

Chromosome

17

Cytoband

Chromosome location (bp)

77086716 - 77217101

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129657 (version 83.38)

Entrez gene

6397

UniProt

Q92503 (UniProt - Evidence at protein level)

neXtProt

NX_Q92503

Antibodypedia

SEC14L1 antibodies

PROTEIN BROWSER

«
SEC14L1-001
SEC14L1-002
SEC14L1-003
SEC14L1-004
SEC14L1-006
SEC14L1-012
SEC14L1-013
SEC14L1-014
SEC14L1-015
SEC14L1-017
SEC14L1-018
SEC14L1-021
SEC14L1-022
SEC14L1-023
SEC14L1-024
SEC14L1-025
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SEC14L1-001
ENSP00000390392
ENST00000436233
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
715 aa
81.2 kDa
No 0
SEC14L1-002
ENSP00000406030
ENST00000443798
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
719 aa
81.8 kDa
No 0
SEC14L1-003
ENSP00000389838
ENST00000431431
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
681 aa
77.1 kDa
No 0
SEC14L1-004
ENSP00000466581
ENST00000585618
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
715 aa
81.2 kDa
No 0
SEC14L1-006
ENSP00000467868
ENST00000587820
K7EQK4 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
60 aa
7.1 kDa
No 0
SEC14L1-012
ENSP00000376268
ENST00000392476
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
719 aa
81.8 kDa
No 0
SEC14L1-013
ENSP00000466079
ENST00000561721
D5G3K4 [Direct mapping]
SEC14-like protein 1; SEC14L1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
14 aa
1.8 kDa
No 0
SEC14L1-014
ENSP00000408169
ENST00000430767
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
715 aa
81.2 kDa
No 0
SEC14L1-015
ENSP00000464973
ENST00000589827
K7EJ08 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
445 aa
51.4 kDa
No 0
SEC14L1-017
ENSP00000465196
ENST00000588880
K7EJJ2 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
15 aa
1.9 kDa
No 0
SEC14L1-018
ENSP00000466220
ENST00000586429
K7ELU0 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
71 aa
8.3 kDa
No 0
SEC14L1-021
ENSP00000466137
ENST00000588616
K7ELM0 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
143 aa
16.7 kDa
No 0
SEC14L1-022
ENSP00000468727
ENST00000590483
K7ESI4 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
89 aa
10.1 kDa
No 0
SEC14L1-023
ENSP00000467347
ENST00000589202
K7EPE4 [Direct mapping]
SEC14-like protein 1
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
156 aa
17 kDa
No 0
SEC14L1-024
ENSP00000464777
ENST00000588488
K7EIJ7 [Direct mapping]
SEC14-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
118 aa
13 kDa
No 0
SEC14L1-025
ENSP00000467934
ENST00000591437
Q92503 [Direct mapping]
SEC14-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
681 aa
77.1 kDa
No 0

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