Cell atlas - AANAT - The Human Protein Atlas

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AANAT

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	AANAT
Gene description	Aralkylamine N-acetyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054321
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054321	A549	Cytosol
	HPA054321	U-2 OS	No staining

GENE INFORMATION
Gene name	AANAT (HGNC Symbol)
Synonyms	SNAT
Description	Aralkylamine N-acetyltransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	76453351 - 76470117
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129673 (version 83.38)
Entrez gene	15
UniProt	Q16613 (UniProt - Evidence at protein level)
neXtProt	NX_Q16613
Antibodypedia	AANAT antibodies

PROTEIN BROWSER

AANAT-001	AANAT-002	AANAT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AANAT-001 ENSP00000250615 ENST00000250615	Q16613 [Direct mapping] Serotonin N-acetyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004059 [aralkylamine N-acetyltransferase activity] GO:0004060 [arylamine N-acetyltransferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006474 [N-terminal protein amino acid acetylation] GO:0007623 [circadian rhythm] GO:0008080 [N-acetyltransferase activity] GO:0009416 [response to light stimulus] GO:0009648 [photoperiodism] GO:0010043 [response to zinc ion] GO:0014070 [response to organic cyclic compound] GO:0030187 [melatonin biosynthetic process] GO:0032868 [response to insulin] GO:0034097 [response to cytokine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0034695 [response to prostaglandin E] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0046688 [response to copper ion] GO:0048471 [perinuclear region of cytoplasm] GO:0051412 [response to corticosterone] GO:0051591 [response to cAMP] GO:0051592 [response to calcium ion] GO:0071320 [cellular response to cAMP] GO:0071889 [14-3-3 protein binding] Show all	252 aa 28.4 kDa	No	0
AANAT-002 ENSP00000376282 ENST00000392492	Q16613 [Direct mapping] Serotonin N-acetyltransferase F1T0I5 [Target identity:100%; Query identity:100%] Arylalkylamine N-acetyltransferase; Serotonin N-acetyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004059 [aralkylamine N-acetyltransferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006474 [N-terminal protein amino acid acetylation] GO:0007623 [circadian rhythm] GO:0008080 [N-acetyltransferase activity] GO:0030187 [melatonin biosynthetic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0071320 [cellular response to cAMP] Show all	207 aa 23.3 kDa	No	0
AANAT-004 ENSP00000468717 ENST00000585649	K7ESH7 [Direct mapping] Serotonin N-acetyltransferase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		152 aa 17.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.