Cell atlas - TTI2 - The Human Protein Atlas

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TTI2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	TTI2
Gene description	TELO2 interacting protein 2
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA023523 , HPA029823
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome.

Main location

Centrosome (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023523	A-431	Nucleoplasm
HPA023523	A-431	Centrosome
HPA023523	U-2 OS	Cytosol
HPA023523	U-251 MG	Nucleoplasm
		Centrosome
		Cytosol
HPA029823	A-431	Nucleoplasm
		Centrosome
		Cytosol
HPA029823	U-2 OS	Centrosome
HPA029823	U-251 MG	Centrosome

GENE INFORMATION
Gene name	TTI2 (HGNC Symbol)
Synonyms	C8orf41, FLJ23263
Description	TELO2 interacting protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	33473386 - 33513601
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129696 (version 83.38)
Entrez gene	80185
UniProt	Q6NXR4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NXR4
Antibodypedia	TTI2 antibodies

PROTEIN BROWSER

TTI2-001	TTI2-002	TTI2-003	TTI2-004	TTI2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTI2-001 ENSP00000411169 ENST00000431156	Q6NXR4 [Direct mapping] TELO2-interacting protein 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	508 aa 56.9 kDa	No	0
TTI2-002 ENSP00000353971 ENST00000360742	Q6NXR4 [Direct mapping] TELO2-interacting protein 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	508 aa 56.9 kDa	No	0
TTI2-003 ENSP00000428569 ENST00000523305	E5RHM7 [Direct mapping] TELO2-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	101 aa 11 kDa	No	0
TTI2-004 ENSP00000428401 ENST00000520636	E5RIH5 [Direct mapping] TELO2-interacting protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	477 aa 53.3 kDa	No	1
TTI2-201 ENSP00000478396 ENST00000613904	Q6NXR4 [Direct mapping] TELO2-interacting protein 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	508 aa 56.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.