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SGOL1

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GENERAL INFORMATION

Gene name

 SGOL1

Gene description

 Shugoshin-like 1 (S. pombe)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SGOL1 (HGNC Symbol)

Synonyms

 NY-BR-85

Description

 Shugoshin-like 1 (S. pombe) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Chromosome

 3

Cytoband

 p24.3

Chromosome location (bp)

 20160593 - 20186292

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129810 (version 83.38)

Entrez gene

 151648

UniProt

 Q5FBB7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5FBB7

Antibodypedia

 SGOL1 antibodies

PROTEIN BROWSER
«
SGOL1-001
SGOL1-002
SGOL1-003
SGOL1-004
SGOL1-005
SGOL1-006
SGOL1-007
SGOL1-009
SGOL1-010
SGOL1-012
SGOL1-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGOL1-001
ENSP00000306581
ENST00000306698
Q5FBB7 [Direct mapping]
Shugoshin-like 1
A0A024R2J4 [Target identity:100%; Query identity:100%]
Shugoshin-like 1 (S. pombe), isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 292 aa
33.5 kDa 		No 0
SGOL1-002
ENSP00000410458
ENST00000412997
Q5FBB7 [Direct mapping]
Shugoshin-like 1
B5BUA4 [Target identity:100%; Query identity:100%]
Shugoshin-like 1 (S. pombe), isoform CRA_a; Shugoshin-like 1 isoform A1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 527 aa
60.1 kDa 		No 0
SGOL1-003
ENSP00000389034
ENST00000437051
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 275 aa
31.3 kDa 		No 0
SGOL1-004
ENSP00000394613
ENST00000417364
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 275 aa
31.3 kDa 		No 0
SGOL1-005
ENSP00000394625
ENST00000419233
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 309 aa
35.3 kDa 		No 0
SGOL1-006
ENSP00000414960
ENST00000425061
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 309 aa
35.3 kDa 		No 0
SGOL1-007
ENSP00000413070
ENST00000443724
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 215 aa
24.6 kDa 		No 0
SGOL1-009
ENSP00000263753
ENST00000263753
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 561 aa
64.2 kDa 		No 0
SGOL1-010
ENSP00000414129
ENST00000421451
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 561 aa
64.2 kDa 		No 0
SGOL1-012
ENSP00000394957
ENST00000442720
Q5FBB7 [Direct mapping]
Shugoshin-like 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 258 aa
29.4 kDa 		No 0
SGOL1-015
ENSP00000411200
ENST00000452020
Q5FBB7 [Direct mapping]
Shugoshin-like 1
A0A024R2J4 [Target identity:100%; Query identity:100%]
Shugoshin-like 1 (S. pombe), isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010457 [centriole-centriole cohesion]
GO:0019900 [kinase binding]
GO:0030892 [mitotic cohesin complex]
GO:0045132 [meiotic chromosome segregation]
GO:0051301 [cell division]
Show all
 292 aa
33.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.