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CDH15

GENERAL INFORMATION

Gene name

 CDH15

Gene description

 Cadherin 15, type 1, M-cadherin (myotubule)

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Group enriched (cerebellum, skeletal muscle)
FANTOM5:Group enriched (cerebellum, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA009139
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, skeletal muscle)

GENE INFORMATION

Gene name

 CDH15 (HGNC Symbol)

Synonyms

 CDH14, CDH3

Description

 Cadherin 15, type 1, M-cadherin (myotubule) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q24.3

Chromosome location (bp)

 89171767 - 89195492

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129910 (version 83.38)

Entrez gene

 1013

UniProt

 P55291 (UniProt - Evidence at protein level)

neXtProt

 NX_P55291

Antibodypedia

 CDH15 antibodies

PROTEIN BROWSER
CDH15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDH15-001
ENSP00000289746
ENST00000289746
P55291 [Direct mapping]
Cadherin-15
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031594 [neuromuscular junction]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042692 [muscle cell differentiation]
GO:0045216 [cell-cell junction organization]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
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 814 aa
88.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.