Expression of DOHH in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Deoxyhypusine hydroxylase/monooxygenase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041953

GENE INFORMATION
Gene name	DOHH (HGNC Symbol)
Synonyms	HLRC1, MGC4293
Description	Deoxyhypusine hydroxylase/monooxygenase (HGNC Symbol)
Entrez gene summary	This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3490821 - 3500940
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129932 (version 83.38)
Entrez gene	83475
UniProt	Q9BU89 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BU89
Antibodypedia	DOHH antibodies

PROTEIN BROWSER

DOHH-001	DOHH-002	DOHH-003	DOHH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOHH-001 ENSP00000250937 ENST00000250937	Q9BU89 [Direct mapping] Deoxyhypusine hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine] GO:0019135 [deoxyhypusine monooxygenase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	302 aa 32.9 kDa	No	0
DOHH-002 ENSP00000464905 ENST00000592858	K7EIV2 [Direct mapping] Deoxyhypusine hydroxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	223 aa 24.4 kDa	No	0
DOHH-003 ENSP00000468416 ENST00000587122	K7ERU8 [Direct mapping] Deoxyhypusine hydroxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	195 aa 20.7 kDa	No	0
DOHH-201 ENSP00000398882 ENST00000427575	Q9BU89 [Direct mapping] Deoxyhypusine hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine] GO:0019135 [deoxyhypusine monooxygenase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	302 aa 32.9 kDa	No	0