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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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LBP
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

LBP

Gene description

Lipopolysaccharide binding protein

Protein class

Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (liver, adipose tissue)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Positivity in plasma and cytoplasmic and membranous expression in glandular cells in gastrointestinal tract and hepatocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 2 antibodies.
HPA001508 , CAB025905
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

LBP (HGNC Symbol)

Synonyms

BPIFD2

Description

Lipopolysaccharide binding protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

Chromosome

20

Cytoband

q11.23

Chromosome location (bp)

38346356 - 38377023

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129988 (version 83.38)

Entrez gene

3929

UniProt

P18428 (UniProt - Evidence at protein level)

neXtProt

NX_P18428

Antibodypedia

LBP antibodies

PROTEIN BROWSER

LBP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LBP-001
ENSP00000217407
ENST00000217407
P18428 [Direct mapping]
Lipopolysaccharide-binding protein
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001889 [liver development]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002281 [macrophage activation involved in immune response]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006968 [cellular defense response]
GO:0008228 [opsonization]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0015920 [lipopolysaccharide transport]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032490 [detection of molecule of bacterial origin]
GO:0032496 [response to lipopolysaccharide]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0043032 [positive regulation of macrophage activation]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0060265 [positive regulation of respiratory burst involved in inflammatory response]
GO:0070062 [extracellular exosome]
GO:0070891 [lipoteichoic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090559 [regulation of membrane permeability]
Show all
481 aa
53.4 kDa
Yes 0

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