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TNNI3

GENERAL INFORMATION

Gene name

 TNNI3

Gene description

 Troponin I type 3 (cardiac)

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (heart muscle)
GTEx:Tissue enriched (heart muscle)
FANTOM5:Tissue enriched (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in cardiac myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA046428 , CAB009349
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION

Gene name

 TNNI3 (HGNC Symbol)

Synonyms

 CMD2A, CMH7, TNNC1

Description

 Troponin I type 3 (cardiac) (HGNC Symbol)

Entrez gene summary

 Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55151767 - 55157773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129991 (version 83.38)

Entrez gene

 7137

UniProt

 P19429 (UniProt - Evidence at protein level)

neXtProt

 NX_P19429

Antibodypedia

 TNNI3 antibodies

PROTEIN BROWSER
TNNI3-001
TNNI3-005
TNNI3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNI3-001
ENSP00000341838
ENST00000344887
P19429 [Direct mapping]
Troponin I, cardiac muscle
Q6FGX2 [Target identity:100%; Query identity:100%]
TNNI3 protein; Troponin I type 3 (Cardiac); Troponin I, cardiac; Troponin I, cardiac variant
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Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001570 [vasculogenesis]
GO:0001980 [regulation of systemic arterial blood pressure by ischemic conditions]
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006937 [regulation of muscle contraction]
GO:0006940 [regulation of smooth muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007507 [heart development]
GO:0019855 [calcium channel inhibitor activity]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031014 [troponin T binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0043292 [contractile fiber]
GO:0046872 [metal ion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060047 [heart contraction]
GO:0060048 [cardiac muscle contraction]
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 210 aa
24 kDa 		No 0
TNNI3-005
ENSP00000465258
ENST00000586858
K7EJP0 [Direct mapping]
Troponin I, cardiac muscle
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 57 aa
6.4 kDa 		No 0
TNNI3-006
ENSP00000466729
ENST00000588882
K7EN02 [Direct mapping]
Troponin I, cardiac muscle
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005861 [troponin complex]
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 185 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.