Expression of ERMARD in cancer - Summary

CANCER ATLAS

Gene description

ER membrane-associated RNA degradation

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041741

GENE INFORMATION
Gene name	ERMARD (HGNC Symbol)
Synonyms	C6orf70, dJ266L20.3, FLJ11152
Description	ER membrane-associated RNA degradation (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains 2 transmembrane domains near the C-terminus and is localized in the endoplasmic reticulum. Knockout of this gene in developing rat brain showed that it may be involved in neuronal migration. Mutations in this gene are associated with periventricular nodular heterotopia-6 (PVNH6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	169751622 - 169781584
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130023 (version 83.38)
Entrez gene	55780
UniProt	Q5T6L9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T6L9
Antibodypedia	ERMARD antibodies

PROTEIN BROWSER

ERMARD-001	ERMARD-002	ERMARD-006	ERMARD-007	ERMARD-008	ERMARD-009	ERMARD-010	ERMARD-011	ERMARD-013	ERMARD-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERMARD-001 ENSP00000355735 ENST00000366773	Q5T6L9 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	678 aa 77.8 kDa	No	2
ERMARD-002 ENSP00000355734 ENST00000366772	Q5T6L9 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	631 aa 72 kDa	No	2
ERMARD-006 ENSP00000397661 ENST00000418781	Q5T6L9 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	605 aa 69 kDa	No	0
ERMARD-007 ENSP00000468240 ENST00000588451	K7ERF7 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	542 aa 62.5 kDa	No	2
ERMARD-008 ENSP00000375945 ENST00000392095	Q5T6L9 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	552 aa 63.6 kDa	No	2
ERMARD-009 ENSP00000468722 ENST00000592367	K7ESI0 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted intracellular proteins Show all		19 aa 2.1 kDa	No	0
ERMARD-010 ENSP00000466474 ENST00000590711	K7EME8 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted intracellular proteins Show all		74 aa 8.2 kDa	No	0
ERMARD-011 ENSP00000466679 ENST00000592745	K7EMW5 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted intracellular proteins Show all		28 aa 3.2 kDa	No	0
ERMARD-013 ENSP00000467665 ENST00000588437		Predicted intracellular proteins Show all		5 aa 0.6 kDa	No	0
ERMARD-016 ENSP00000468124 ENST00000586341	K7ER62 [Direct mapping] Endoplasmic reticulum membrane-associated RNA degradation protein Show all	Predicted intracellular proteins Show all		174 aa 19.7 kDa	No	0