Cell atlas - XPO7 - The Human Protein Atlas

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XPO7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	XPO7
Gene description	Exportin 7
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048153
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048153	A-431	Nucleus	Intensity
	HPA048153	U-2 OS	No staining
	HPA048153	U-251 MG	No staining

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000022100 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048153	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	XPO7 (HGNC Symbol)
Synonyms	KIAA0745, RANBP16
Description	Exportin 7 (HGNC Symbol)
Entrez gene summary	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	21919671 - 22006585
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130227 (version 83.38)
Entrez gene	23039
UniProt	Q9UIA9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIA9
Antibodypedia	XPO7 antibodies

PROTEIN BROWSER

XPO7-001	XPO7-003	XPO7-008	XPO7-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XPO7-001 ENSP00000252512 ENST00000252512	Q9UIA9 [Direct mapping] Exportin-7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005049 [nuclear export signal receptor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0051028 [mRNA transport] Show all	1087 aa 123.9 kDa	No	1
XPO7-003 ENSP00000410249 ENST00000433566	E7ESC6 [Direct mapping] Exportin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	1088 aa 124.1 kDa	No	1
XPO7-008 ENSP00000429290 ENST00000521303	H0YBE1 [Direct mapping] Exportin-7 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	190 aa 21.6 kDa	No	0
XPO7-012 ENSP00000429317 ENST00000517551	E5RIW1 [Direct mapping] Exportin-7 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	237 aa 26.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.