Tissue expression of ATP8B3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP8B3
Gene description	ATPase, aminophospholipid transporter, class I, type 8B, member 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	ATP8B3 (HGNC Symbol)
Synonyms	ATPIK
Description	ATPase, aminophospholipid transporter, class I, type 8B, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1782075 - 1812276
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000130270 (version 83.38)
Entrez gene	148229
UniProt	O60423 (UniProt - Evidence at transcript level)
neXtProt	NX_O60423
Antibodypedia	ATP8B3 antibodies

PROTEIN BROWSER

ATP8B3-001	ATP8B3-002	ATP8B3-005	ATP8B3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP8B3-001 ENSP00000445204 ENST00000526092	F5H3R9 [Direct mapping] Phospholipid-transporting ATPase IK Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	562 aa 64 kDa	No	4
ATP8B3-002 ENSP00000311336 ENST00000310127	O60423 [Direct mapping] Phospholipid-transporting ATPase IK Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0001669 [acrosomal vesicle] GO:0002080 [acrosomal membrane] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0007339 [binding of sperm to zona pellucida] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1300 aa 146.8 kDa	No	>9
ATP8B3-005 ENSP00000437115 ENST00000525591	O60423 [Direct mapping] Phospholipid-transporting ATPase IK Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0002080 [acrosomal membrane] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1263 aa 143.7 kDa	No	>9
ATP8B3-009 ENSP00000465027 ENST00000587160	K7EJ52 [Direct mapping] Phospholipid-transporting ATPase IK Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	205 aa 22.9 kDa	No	2