We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
EPO
  • premium

    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EPO

Gene description

Erythropoietin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cervix, uterine, endometrium, liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enhanced (cervix, uterine, endometrium)

Protein evidence

Evidence at protein level

Protein expression

Low cytoplasmic expression in renal tubules with distinct positivity in erythrocytes.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 1 antibody.
CAB010336
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, endometrium, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, endometrium)

GENE INFORMATION

Gene name

EPO (HGNC Symbol)

Synonyms

EP

Description

Erythropoietin (HGNC Symbol)

Entrez gene summary

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

100720800 - 100723700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130427 (version 83.38)

Entrez gene

2056

UniProt

P01588 (UniProt - Evidence at protein level)

neXtProt

NX_P01588

Antibodypedia

EPO antibodies

PROTEIN BROWSER

EPO-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPO-001
ENSP00000252723
ENST00000252723
P01588 [Direct mapping]
Erythropoietin
G9JKG7 [Target identity:100%; Query identity:100%]
Erythropoietin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001666 [response to hypoxia]
GO:0005128 [erythropoietin receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006953 [acute-phase response]
GO:0007165 [signal transduction]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0010976 [positive regulation of neuron projection development]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030218 [erythrocyte differentiation]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0033189 [response to vitamin A]
GO:0033574 [response to testosterone]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042541 [hemoglobin biosynthetic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043249 [erythrocyte maturation]
GO:0043627 [response to estrogen]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045740 [positive regulation of DNA replication]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048678 [response to axon injury]
GO:0051602 [response to electrical stimulus]
GO:0055093 [response to hyperoxia]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0071456 [cellular response to hypoxia]
GO:0071474 [cellular hyperosmotic response]
GO:1901215 [negative regulation of neuron death]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
GO:1902251 [negative regulation of erythrocyte apoptotic process]
GO:2001258 [negative regulation of cation channel activity]
Show all
193 aa
21.3 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.