Expression of PXDN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peroxidasin

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012375

GENE INFORMATION
Gene name	PXDN (HGNC Symbol)
Synonyms	D2S448, D2S448E, KIAA0230, MG50, PRG2, PXN
Description	Peroxidasin (HGNC Symbol)
Entrez gene summary	This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	1631887 - 1744852
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130508 (version 83.38)
Entrez gene	7837
UniProt	Q92626 (UniProt - Evidence at protein level)
neXtProt	NX_Q92626
Antibodypedia	PXDN antibodies

PROTEIN BROWSER

PXDN-001	PXDN-002	PXDN-006	PXDN-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PXDN-001 ENSP00000252804 ENST00000252804	Q92626 [Direct mapping] Peroxidasin homolog Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001960 [negative regulation of cytokine-mediated signaling pathway] GO:0004601 [peroxidase activity] GO:0005152 [interleukin-1 receptor antagonist activity] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0006955 [immune response] GO:0006979 [response to oxidative stress] GO:0020037 [heme binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0042744 [hydrogen peroxide catabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	1479 aa 165.3 kDa	Yes	0
PXDN-002 ENSP00000402738 ENST00000433670	H7C1W1 [Direct mapping] Peroxidasin homolog Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	723 aa 79.8 kDa	Yes	0
PXDN-006 ENSP00000398363 ENST00000425171	C9J4I9 [Direct mapping] Peroxidasin homolog Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	224 aa 25.6 kDa	Yes	0
PXDN-007 ENSP00000408701 ENST00000447941	H7C300 [Direct mapping] Peroxidasin homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	197 aa 22.3 kDa	No	0