Tissue expression of CRB3 - Summary - The Human Protein Atlas

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CRB3

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CRB3
Gene description	Crumbs family member 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Expression in cytoplasm and apical membranes mainly in GI.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA013835
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CRB3 (HGNC Symbol)
Synonyms	MGC17303
Description	Crumbs family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6463777 - 6467221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130545 (version 83.38)
Entrez gene	92359
UniProt	Q9BUF7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUF7
Antibodypedia	CRB3 antibodies

PROTEIN BROWSER

CRB3-001	CRB3-002	CRB3-003	CRB3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRB3-001 ENSP00000349204 ENST00000356762	Q9BUF7 [Direct mapping] Protein crumbs homolog 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017124 [SH3 domain binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0043234 [protein complex] GO:0045177 [apical part of cell] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] GO:0072659 [protein localization to plasma membrane] Show all	123 aa 13.1 kDa	Yes	1
CRB3-002 ENSP00000472010 ENST00000600229	Q9BUF7 [Direct mapping] Protein crumbs homolog 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017124 [SH3 domain binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] GO:0072659 [protein localization to plasma membrane] Show all	120 aa 12.9 kDa	Yes	1
CRB3-003 ENSP00000469707 ENST00000598494	Q9BUF7 [Direct mapping] Protein crumbs homolog 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017124 [SH3 domain binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] GO:0072659 [protein localization to plasma membrane] Show all	120 aa 12.9 kDa	Yes	1
CRB3-004 ENSP00000310123 ENST00000308243	Q9BUF7 [Direct mapping] Protein crumbs homolog 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017124 [SH3 domain binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] GO:0072659 [protein localization to plasma membrane] Show all	120 aa 12.9 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.