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SAG

GENERAL INFORMATION

Gene name

 SAG

Gene description

 S-antigen; retina and pineal gland (arrestin)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Group enriched (testis, caudate)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in retina.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA004946
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 SAG (HGNC Symbol)

Synonyms

 ARRESTIN, RP47

Description

 S-antigen; retina and pineal gland (arrestin) (HGNC Symbol)

Entrez gene summary

 Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 233307816 - 233347055

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130561 (version 83.38)

Entrez gene

 6295

UniProt

 P10523 (UniProt - Evidence at protein level)

neXtProt

 NX_P10523

Antibodypedia

 SAG antibodies

PROTEIN BROWSER
SAG-001
SAG-007
SAG-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAG-001
ENSP00000386444
ENST00000409110
P10523 [Direct mapping]
S-arrestin
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0002046 [opsin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0043086 [negative regulation of catalytic activity]
GO:0051219 [phosphoprotein binding]
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 405 aa
45.1 kDa 		No 0
SAG-007
ENSP00000408937
ENST00000447536
E7ESX4 [Direct mapping]
S-arrestin
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Predicted intracellular proteins
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GO:0007165 [signal transduction]
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 169 aa
18.7 kDa 		No 0
SAG-008
ENSP00000409475
ENST00000415974
C9JSX4 [Direct mapping]
S-arrestin
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Predicted intracellular proteins
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GO:0007165 [signal transduction]
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 130 aa
14 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.