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TNNT3

GENERAL INFORMATION

Gene name

 TNNT3

Gene description

 Troponin T type 3 (skeletal, fast)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA037810 , HPA056909 , CAB002451
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 TNNT3 (HGNC Symbol)

Synonyms

 AMCD2B, DA2B, DKFZp779M2348, FSSV

Description

 Troponin T type 3 (skeletal, fast) (HGNC Symbol)

Entrez gene summary

 The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1919562 - 1938706

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130595 (version 83.38)

Entrez gene

 7140

UniProt

 P45378 (UniProt - Evidence at protein level)

neXtProt

 NX_P45378

Antibodypedia

 TNNT3 antibodies

PROTEIN BROWSER
«
TNNT3-001
TNNT3-002
TNNT3-003
TNNT3-004
TNNT3-006
TNNT3-007
TNNT3-010
TNNT3-011
TNNT3-012
TNNT3-014
TNNT3-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNT3-001
ENSP00000278317
ENST00000278317
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 258 aa
30.6 kDa 		No 0
TNNT3-002
ENSP00000371001
ENST00000381589
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 256 aa
30.3 kDa 		No 0
TNNT3-003
ENSP00000370991
ENST00000381579
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 250 aa
29.7 kDa 		No 0
TNNT3-004
ENSP00000370970
ENST00000381558
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 250 aa
29.7 kDa 		No 0
TNNT3-006
ENSP00000370969
ENST00000381557
F8WA37 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
Show all
 244 aa
28.9 kDa 		No 0
TNNT3-007
ENSP00000415614
ENST00000453458
C9JCA5 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
Show all
 208 aa
25 kDa 		No 0
TNNT3-010
ENSP00000380468
ENST00000397301
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 269 aa
31.8 kDa 		No 0
TNNT3-011
ENSP00000344870
ENST00000344578
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 245 aa
29.1 kDa 		No 0
TNNT3-012
ENSP00000370975
ENST00000381563
P45378 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030899 [calcium-dependent ATPase activity]
GO:0031013 [troponin I binding]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
Show all
 261 aa
31 kDa 		No 0
TNNT3-014
ENSP00000380471
ENST00000397304
H9KVA2 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
Show all
 239 aa
28.3 kDa 		No 0
TNNT3-015
ENSP00000413203
ENST00000446240
C9JZN9 [Direct mapping]
Troponin T, fast skeletal muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006942 [regulation of striated muscle contraction]
Show all
 239 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.