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ATXN10

GENERAL INFORMATION

Gene name

 ATXN10

Gene description

 Ataxin 10

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049531
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATXN10 (HGNC Symbol)

Synonyms

 E46L, FLJ37990, SCA10

Description

 Ataxin 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45671798 - 45845307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130638 (version 83.38)

Entrez gene

 25814

UniProt

 Q9UBB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBB4

Antibodypedia

 ATXN10 antibodies

PROTEIN BROWSER
ATXN10-001
ATXN10-009
ATXN10-010
ATXN10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATXN10-001
ENSP00000252934
ENST00000252934
Q9UBB4 [Direct mapping]
Ataxin-10
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030425 [dendrite]
GO:0031175 [neuron projection development]
GO:0042384 [cilium assembly]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070207 [protein homotrimerization]
Show all
 475 aa
53.5 kDa 		No 0
ATXN10-009
ENSP00000385624
ENST00000402380
B1AHE3 [Direct mapping]
Ataxin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
14.2 kDa 		No 0
ATXN10-010
ENSP00000391117
ENST00000435026
B1AHE4 [Direct mapping]
Ataxin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 197 aa
21.9 kDa 		No 0
ATXN10-201
ENSP00000370449
ENST00000381061
Q9UBB4 [Direct mapping]
Ataxin-10
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0031175 [neuron projection development]
GO:0043025 [neuronal cell body]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 411 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.