Tissue expression of MNX1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MNX1
Gene description	Motor neuron and pancreas homeobox 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum, small intestine)
GTEx:	Tissue enhanced (pancreas, small intestine)
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	MNX1 (HGNC Symbol)
Synonyms	HB9, HLXB9, HOXHB9, SCRA1
Description	Motor neuron and pancreas homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	156994051 - 157010651
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130675 (version 83.38)
Entrez gene	3110
UniProt	P50219 (UniProt - Evidence at protein level)
neXtProt	NX_P50219
Antibodypedia	MNX1 antibodies

PROTEIN BROWSER

MNX1-001	MNX1-003	MNX1-004	MNX1-005	MNX1-006	MNX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MNX1-001 ENSP00000252971 ENST00000252971	P50219 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] GO:0008045 [motor neuron axon guidance] GO:0009653 [anatomical structure morphogenesis] GO:0009791 [post-embryonic development] GO:0021520 [spinal cord motor neuron cell fate specification] GO:0021675 [nerve development] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021953 [central nervous system neuron differentiation] GO:0030182 [neuron differentiation] GO:0031016 [pancreas development] GO:0031018 [endocrine pancreas development] GO:0043565 [sequence-specific DNA binding] GO:0048667 [cell morphogenesis involved in neuron differentiation] GO:0048812 [neuron projection morphogenesis] GO:0060539 [diaphragm development] GO:0060541 [respiratory system development] Show all	401 aa 40.6 kDa	No	0
MNX1-003 ENSP00000474286 ENST00000479817	S4R3G1 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.2 kDa	No	0
MNX1-004 ENSP00000401158 ENST00000428439	C9K088 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	82 aa 9.3 kDa	No	0
MNX1-005 ENSP00000416458 ENST00000425745	C9JFT4 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		29 aa 2.8 kDa	No	0
MNX1-006 ENSP00000475129 ENST00000469500	S4R464 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.5 kDa	No	0
MNX1-201 ENSP00000438552 ENST00000543409	P50219 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] GO:0009653 [anatomical structure morphogenesis] GO:0021520 [spinal cord motor neuron cell fate specification] GO:0031018 [endocrine pancreas development] GO:0043565 [sequence-specific DNA binding] GO:0048812 [neuron projection morphogenesis] Show all	189 aa 20.6 kDa	No	0