Cell atlas - POMT1 - The Human Protein Atlas

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POMT1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	POMT1
Gene description	Protein-O-mannosyltransferase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065252
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065252	HEK 293	Golgi apparatus
	HPA065252	MCF7	Golgi apparatus
	HPA065252	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	POMT1 (HGNC Symbol)
Synonyms	LGMD2K
Description	Protein-O-mannosyltransferase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Chromosome	9
Cytoband	q34.13
Chromosome location (bp)	131502902 - 131523806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130714 (version 83.38)
Entrez gene	10585
UniProt	Q9Y6A1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6A1
Antibodypedia	POMT1 antibodies

PROTEIN BROWSER

POMT1-001	POMT1-002	POMT1-003	POMT1-005	POMT1-006	POMT1-007	POMT1-008	POMT1-009	POMT1-012	POMT1-201	POMT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POMT1-001 ENSP00000361302 ENST00000372228	Q9Y6A1 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0000032 [cell wall mannoprotein biosynthetic process] GO:0001669 [acrosomal vesicle] GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0030198 [extracellular matrix organization] GO:0031502 [dolichyl-phosphate-mannose-protein mannosyltransferase complex] GO:0035269 [protein O-linked mannosylation] GO:0044845 [chain elongation of O-linked mannose residue] GO:0046872 [metal ion binding] GO:1900101 [regulation of endoplasmic reticulum unfolded protein response] Show all	747 aa 84.9 kDa	No	>9
POMT1-002 ENSP00000343034 ENST00000341012	Q9Y6A1 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0000032 [cell wall mannoprotein biosynthetic process] GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031502 [dolichyl-phosphate-mannose-protein mannosyltransferase complex] GO:0035269 [protein O-linked mannosylation] GO:0044845 [chain elongation of O-linked mannose residue] GO:0046872 [metal ion binding] GO:1900101 [regulation of endoplasmic reticulum unfolded protein response] Show all	671 aa 76.3 kDa	No	>9
POMT1-003 ENSP00000385797 ENST00000402686	Q9Y6A1 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0000032 [cell wall mannoprotein biosynthetic process] GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031502 [dolichyl-phosphate-mannose-protein mannosyltransferase complex] GO:0035269 [protein O-linked mannosylation] GO:0044845 [chain elongation of O-linked mannose residue] GO:0046872 [metal ion binding] GO:1900101 [regulation of endoplasmic reticulum unfolded protein response] Show all	725 aa 82.6 kDa	No	>9
POMT1-005 ENSP00000395060 ENST00000441334	Q5JT03 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097502 [mannosylation] Show all	297 aa 33.3 kDa	No	6
POMT1-006 ENSP00000403736 ENST00000448212	Q5JT07 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097502 [mannosylation] Show all	218 aa 23.9 kDa	No	7
POMT1-007 ENSP00000405149 ENST00000415075	Q5JT04 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097502 [mannosylation] Show all	156 aa 17.6 kDa	No	2
POMT1-008 ENSP00000402083 ENST00000430619	Q5JT05 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097502 [mannosylation] Show all	168 aa 18.8 kDa	No	5
POMT1-009 ENSP00000390737 ENST00000418774	Q5JSZ6 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097502 [mannosylation] Show all	142 aa 15.8 kDa	No	2
POMT1-012 ENSP00000361294 ENST00000372220	Q5JT02 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	346 aa 39.4 kDa	No	4
POMT1-201 ENSP00000384531 ENST00000404875	Q9Y6A1 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0000032 [cell wall mannoprotein biosynthetic process] GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031502 [dolichyl-phosphate-mannose-protein mannosyltransferase complex] GO:0035269 [protein O-linked mannosylation] GO:0044845 [chain elongation of O-linked mannose residue] GO:0046872 [metal ion binding] GO:1900101 [regulation of endoplasmic reticulum unfolded protein response] Show all	608 aa 69.5 kDa	No	9
POMT1-202 ENSP00000404119 ENST00000423007	Q9Y6A1 [Direct mapping] Protein O-mannosyl-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0000032 [cell wall mannoprotein biosynthetic process] GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031502 [dolichyl-phosphate-mannose-protein mannosyltransferase complex] GO:0035269 [protein O-linked mannosylation] GO:0044845 [chain elongation of O-linked mannose residue] GO:0046872 [metal ion binding] GO:1900101 [regulation of endoplasmic reticulum unfolded protein response] Show all	725 aa 82.6 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.