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ATG4D

CANCER ATLAS

Gene description

 Autophagy related 4D, cysteine peptidase

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA067683

GENE INFORMATION

Gene name

 ATG4D (HGNC Symbol)

Synonyms

 APG4-D, APG4D, AUTL4

Description

 Autophagy related 4D, cysteine peptidase (HGNC Symbol)

Entrez gene summary

 Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10543895 - 10553418

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130734 (version 83.38)

Entrez gene

 84971

UniProt

 Q86TL0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TL0

Antibodypedia

 ATG4D antibodies

PROTEIN BROWSER
ATG4D-001
ATG4D-007
ATG4D-008
ATG4D-009
ATG4D-010
ATG4D-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG4D-001
ENSP00000311318
ENST00000309469
Q86TL0 [Direct mapping]
Cysteine protease ATG4D Cysteine protease ATG4D, mitochondrial
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006915 [apoptotic process]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 474 aa
52.9 kDa 		No 0
ATG4D-007
ENSP00000467223
ENST00000586477
K7EP43 [Direct mapping]
Cysteine protease ATG4D
Show all
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 209 aa
23.3 kDa 		No 0
ATG4D-008
ENSP00000465089
ENST00000586863
K7EJA5 [Direct mapping]
Cysteine protease ATG4D
Show all
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 177 aa
19.9 kDa 		No 0
ATG4D-009
ENSP00000468780
ENST00000587256
K7ESM7 [Direct mapping]
Cysteine protease ATG4D
Show all
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 203 aa
22.7 kDa 		No 0
ATG4D-010
ENSP00000466759
ENST00000588972
K7EN30 [Direct mapping]
Cysteine protease ATG4D
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 177 aa
19.7 kDa 		No 0
ATG4D-011
ENSP00000467694
ENST00000585437
K7EQ67 [Direct mapping]
Cysteine protease ATG4D
Show all
Predicted intracellular proteins
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 99 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.