Tissue expression of NPAS1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPAS1
Gene description	Neuronal PAS domain protein 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (skin, cerebral cortex, stomach, spleen)
GTEx:	Tissue enhanced (cerebral cortex)
FANTOM5:	Tissue enhanced (hippocampus, brain, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skin, cerebral cortex, stomach, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, brain, retina)

GENE INFORMATION
Gene name	NPAS1 (HGNC Symbol)
Synonyms	bHLHe11, MOP5, PASD5
Description	Neuronal PAS domain protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	47019820 - 47045775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130751 (version 83.38)
Entrez gene	4861
UniProt	Q99742 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99742
Antibodypedia	NPAS1 antibodies

PROTEIN BROWSER

NPAS1-001	NPAS1-002	NPAS1-003	NPAS1-004	NPAS1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPAS1-001 ENSP00000469142 ENST00000602212	Q99742 [Direct mapping] Neuronal PAS domain-containing protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001964 [startle response] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007417 [central nervous system development] GO:0042711 [maternal behavior] GO:0046983 [protein dimerization activity] Show all	590 aa 62.7 kDa	No	0
NPAS1-002 ENSP00000472679 ENST00000602189	M0R2M8 [Direct mapping] Neuronal PAS domain-containing protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	415 aa 44.1 kDa	No	0
NPAS1-003 ENSP00000405290 ENST00000449844	Q99742 [Direct mapping] Neuronal PAS domain-containing protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007417 [central nervous system development] GO:0046983 [protein dimerization activity] Show all	590 aa 62.7 kDa	No	0
NPAS1-004 ENSP00000398689 ENST00000439365	Q99742 [Direct mapping] Neuronal PAS domain-containing protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007417 [central nervous system development] GO:0046983 [protein dimerization activity] Show all	234 aa 25 kDa	No	0
NPAS1-006 ENSP00000472075 ENST00000594670	M0R1R8 [Direct mapping] Neuronal PAS domain-containing protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	214 aa 22.9 kDa	No	0