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ARHGEF16

CANCER ATLAS

Gene description

 Rho guanine nucleotide exchange factor (GEF) 16

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010609

GENE INFORMATION

Gene name

 ARHGEF16 (HGNC Symbol)

Synonyms

 GEF16, NBR

Description

 Rho guanine nucleotide exchange factor (GEF) 16 (HGNC Symbol)

Entrez gene summary

 Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.32

Chromosome location (bp)

 3454426 - 3481113

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130762 (version 83.38)

Entrez gene

 27237

UniProt

 Q5VV41 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VV41

Antibodypedia

 ARHGEF16 antibodies

PROTEIN BROWSER
ARHGEF16-001
ARHGEF16-002
ARHGEF16-003
ARHGEF16-005
ARHGEF16-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF16-001
ENSP00000367629
ENST00000378378
Q5VV41 [Direct mapping]
Rho guanine nucleotide exchange factor 16
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017048 [Rho GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060326 [cell chemotaxis]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097190 [apoptotic signaling pathway]
Show all
 709 aa
80.1 kDa 		No 0
ARHGEF16-002
ENSP00000367624
ENST00000378373
Q5VV41 [Direct mapping]
Rho guanine nucleotide exchange factor 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017048 [Rho GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060326 [cell chemotaxis]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097190 [apoptotic signaling pathway]
Show all
 421 aa
48.6 kDa 		No 0
ARHGEF16-003
ENSP00000367622
ENST00000378371
Q5VV41 [Direct mapping]
Rho guanine nucleotide exchange factor 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017048 [Rho GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060326 [cell chemotaxis]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097190 [apoptotic signaling pathway]
Show all
 421 aa
48.6 kDa 		No 0
ARHGEF16-005
ENSP00000411936
ENST00000445297
B0QZD3 [Direct mapping]
Rho guanine nucleotide exchange factor 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 146 aa
17.1 kDa 		No 0
ARHGEF16-007
ENSP00000390853
ENST00000418137
B0QZD4 [Direct mapping]
Rho guanine nucleotide exchange factor 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 180 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.