Fields »
ABOUT
HELP
BLOG
MED18

GENERAL INFORMATION

Gene name

 MED18

Gene description

 Mediator complex subunit 18

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in a majority of tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA027429
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MED18 (HGNC Symbol)

Synonyms

 FLJ20045, p28b

Description

 Mediator complex subunit 18 (HGNC Symbol)

Entrez gene summary

 MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 28329002 - 28335967

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130772 (version 83.38)

Entrez gene

 54797

UniProt

 Q9BUE0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUE0

Antibodypedia

 MED18 antibodies

PROTEIN BROWSER
MED18-001
MED18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED18-001
ENSP00000362948
ENST00000373842
Q9BUE0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 18
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0016592 [mediator complex]
GO:0070847 [core mediator complex]
Show all
 208 aa
23.7 kDa 		No 0
MED18-201
ENSP00000381963
ENST00000398997
Q9BUE0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 18
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0016592 [mediator complex]
GO:0070847 [core mediator complex]
Show all
 208 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.