Expression of PPAN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peter pan homolog (Drosophila)

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043265

GENE INFORMATION
Gene name	PPAN (HGNC Symbol)
Synonyms	BXDC3, SSF, SSF1, SSF2
Description	Peter pan homolog (Drosophila) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10106289 - 10111634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130810 (version 83.38)
Entrez gene	56342
UniProt	Q9NQ55 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NQ55
Antibodypedia	PPAN antibodies

PROTEIN BROWSER

PPAN-001	PPAN-002	PPAN-003	PPAN-004	PPAN-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPAN-001 ENSP00000253107 ENST00000253107	Q9NQ55 [Direct mapping] Suppressor of SWI4 1 homolog Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0000027 [ribosomal large subunit assembly] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0019843 [rRNA binding] GO:0030687 [preribosome, large subunit precursor] GO:0044822 [poly(A) RNA binding] Show all	473 aa 53.2 kDa	No	0
PPAN-002 ENSP00000377382 ENST00000393793	A8MV53 [Direct mapping] HCG2033702, isoform CRA_a; Suppressor of SWI4 1 homolog Show all	Predicted intracellular proteins Show all		420 aa 47.1 kDa	No	0
PPAN-003 ENSP00000410485 ENST00000446223	C9J3W3 [Direct mapping] Suppressor of SWI4 1 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		210 aa 23.6 kDa	No	0
PPAN-004 ENSP00000415988 ENST00000430370	C9JHF7 [Direct mapping] Suppressor of SWI4 1 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		97 aa 11 kDa	No	0
PPAN-009 ENSP00000415467 ENST00000444703	H7C446 [Direct mapping] Suppressor of SWI4 1 homolog Show all	Predicted intracellular proteins Show all		208 aa 23.1 kDa	No	0