Cell atlas - SLC6A8 - The Human Protein Atlas

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SLC6A8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC6A8
Gene description	Solute carrier family 6 (neurotransmitter transporter), member 8
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC6A8 (HGNC Symbol)
Synonyms	CRTR, CT1
Description	Solute carrier family 6 (neurotransmitter transporter), member 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153688099 - 153696593
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130821 (version 83.38)
Entrez gene	6535
UniProt	P48029 (UniProt - Evidence at protein level)
neXtProt	NX_P48029
Antibodypedia	SLC6A8 antibodies

PROTEIN BROWSER

SLC6A8-001	SLC6A8-002	SLC6A8-005	SLC6A8-006	SLC6A8-008	SLC6A8-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A8-001 ENSP00000394742 ENST00000457723	H7C0F5 [Direct mapping] Sodium- and chloride-dependent creatine transporter 1 Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.4 kDa	No	0
SLC6A8-002 ENSP00000253122 ENST00000253122	P48029 [Direct mapping] Sodium- and chloride-dependent creatine transporter 1 X5D9C4 [Target identity:100%; Query identity:100%] Transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005308 [creatine transmembrane transporter activity] GO:0005309 [creatine:sodium symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006836 [neurotransmitter transport] GO:0006936 [muscle contraction] GO:0008150 [biological_process] GO:0015881 [creatine transport] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:1902598 [creatine transmembrane transport] Show all	635 aa 70.5 kDa	No	>9
SLC6A8-005 ENSP00000403041 ENST00000430077	P48029 [Direct mapping] Sodium- and chloride-dependent creatine transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005308 [creatine transmembrane transporter activity] GO:0005309 [creatine:sodium symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006836 [neurotransmitter transport] GO:0006936 [muscle contraction] GO:0008150 [biological_process] GO:0015881 [creatine transport] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:1902598 [creatine transmembrane transport] Show all	520 aa 58.5 kDa	No	>9
SLC6A8-006 ENSP00000404046 ENST00000429147	H7C249 [Direct mapping] Sodium- and chloride-dependent creatine transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	112 aa 12.1 kDa	No	1
SLC6A8-008 ENSP00000400463 ENST00000413787	H7C1I2 [Direct mapping] Sodium- and chloride-dependent creatine transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	156 aa 17.5 kDa	No	2
SLC6A8-009 ENSP00000403682 ENST00000442457	H7C222 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	174 aa 19 kDa	No	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.