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DUSP9

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GENERAL INFORMATION

Gene name

 DUSP9

Gene description

 Dual specificity phosphatase 9

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the endoplasmic reticulum.

RNA cell category

 Cell line enriched (Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA003336
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003336 Hep G2 Nucleoplasm
Endoplasmic reticulum
HPA003336 PC-3 Endoplasmic reticulum
HPA003336 U-2 OS Endoplasmic reticulum

GENE INFORMATION

Gene name

 DUSP9 (HGNC Symbol)

Synonyms

 MKP-4, MKP4

Description

 Dual specificity phosphatase 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153642492 - 153651326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130829 (version 83.38)

Entrez gene

 1852

UniProt

 Q99956 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99956

Antibodypedia

 DUSP9 antibodies

PROTEIN BROWSER
DUSP9-001
DUSP9-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP9-001
ENSP00000359186
ENST00000370167
Q99956 [Direct mapping]
Dual specificity protein phosphatase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 384 aa
41.9 kDa 		No 0
DUSP9-003
ENSP00000345853
ENST00000342782
Q99956 [Direct mapping]
Dual specificity protein phosphatase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000188 [inactivation of MAPK activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 384 aa
41.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.