Cell atlas - ZNF331 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ZNF331
Gene description	Zinc finger protein 331
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	18
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063157
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063157	HEK 293	Nucleoplasm
	HPA063157	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ZNF331 (HGNC Symbol)
Synonyms	RITA, ZNF361, ZNF463
Description	Zinc finger protein 331 (HGNC Symbol)
Entrez gene summary	This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	53520981 - 53580269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130844 (version 83.38)
Entrez gene	55422
UniProt	Q9NQX6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQX6
Antibodypedia	ZNF331 antibodies

PROTEIN BROWSER

ZNF331-001	ZNF331-002	ZNF331-003	ZNF331-004	ZNF331-005	ZNF331-006	ZNF331-007	ZNF331-008	ZNF331-011	ZNF331-013	ZNF331-015	ZNF331-016	ZNF331-017	ZNF331-018	ZNF331-019	ZNF331-020	ZNF331-022	ZNF331-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF331-001 ENSP00000421014 ENST00000511154	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-002 ENSP00000423156 ENST00000513999	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-003 ENSP00000425517 ENST00000504493	Q71QC6 [Direct mapping] KRAB zinc finger protein; Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	66 aa 7.6 kDa	No	0
ZNF331-004 ENSP00000393336 ENST00000411977	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-005 ENSP00000424929 ENST00000505426	Q71QC9 [Direct mapping] KRAB zinc finger protein; Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	64 aa 7.4 kDa	No	0
ZNF331-006 ENSP00000422586 ENST00000502616	Q71QC5 [Direct mapping] KRAB zinc finger protein; Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	85 aa 9.8 kDa	No	0
ZNF331-007 ENSP00000421728 ENST00000512387	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-008 ENSP00000253144 ENST00000253144	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-011 ENSP00000423675 ENST00000502248	E7EV14 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	63 aa 7.2 kDa	No	0
ZNF331-013 ENSP00000424835 ENST00000514374	E7EWU7 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 11.6 kDa	No	0
ZNF331-015 ENSP00000422471 ENST00000514022	E7ERM8 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	167 aa 19.5 kDa	No	0
ZNF331-016 ENSP00000426127 ENST00000511567	E7EPT0 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	105 aa 12.2 kDa	No	0
ZNF331-017 ENSP00000426458 ENST00000513265	E7EPG5 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	98 aa 11.4 kDa	No	0
ZNF331-018 ENSP00000427532 ENST00000505949	E7ETJ5 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	177 aa 20.8 kDa	No	0
ZNF331-019 ENSP00000423263 ENST00000509047	E7ENR0 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	87 aa 10 kDa	No	0
ZNF331-020 ENSP00000426155 ENST00000509585	D6RH27 [Direct mapping] Zinc finger protein 331 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	47 aa 5.4 kDa	No	0
ZNF331-022 ENSP00000427439 ENST00000511593	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0
ZNF331-201 ENSP00000393817 ENST00000449416	Q9NQX6 [Direct mapping] Zinc finger protein 331 A0A024R4J5 [Target identity:100%; Query identity:100%] Zinc finger protein 331, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	463 aa 53.7 kDa	No	0