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Skin cancers and a few cases of squamous cell carcinomas in cervix showed moderate to strong nuclear immunoreactivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CASZ1 (HGNC Symbol)
Synonyms
castor, cst, FLJ20321, SRG, ZNF693
Description
Castor zinc finger 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Q86V15 [Direct mapping] Zinc finger protein castor homolog 1
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q86V15 [Direct mapping] Zinc finger protein castor homolog 1
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043231 [intracellular membrane-bounded organelle] GO:0045665 [negative regulation of neuron differentiation] GO:0046872 [metal ion binding] GO:0060040 [retinal bipolar neuron differentiation] GO:0060223 [retinal rod cell fate commitment] GO:0060226 [negative regulation of retinal cone cell fate commitment] GO:1902870 [negative regulation of amacrine cell differentiation]
