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Hepatocellular carcinomas showed weak to moderate cytoplasmic and nuclear immunoreactivity. Remaining cancer cells were generally negative.
GENE INFORMATION
Gene name
RGN (HGNC Symbol)
Synonyms
RC, SMP30
Description
Regucalcin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Q15493 [Direct mapping] Regucalcin V9HWF8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 41
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q15493 [Direct mapping] Regucalcin V9HWF8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 41
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development] GO:0001889 [liver development] GO:0001933 [negative regulation of protein phosphorylation] GO:0004341 [gluconolactonase activity] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006469 [negative regulation of protein kinase activity] GO:0006874 [cellular calcium ion homeostasis] GO:0007283 [spermatogenesis] GO:0007568 [aging] GO:0008270 [zinc ion binding] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010907 [positive regulation of glucose metabolic process] GO:0010922 [positive regulation of phosphatase activity] GO:0019853 [L-ascorbic acid biosynthetic process] GO:0030234 [enzyme regulator activity] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0032781 [positive regulation of ATPase activity] GO:0034260 [negative regulation of GTPase activity] GO:0043066 [negative regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0045019 [negative regulation of nitric oxide biosynthetic process] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050848 [regulation of calcium-mediated signaling] GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0097421 [liver regeneration] GO:1901318 [negative regulation of sperm motility] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901896 [positive regulation of calcium-transporting ATPase activity] GO:1902679 [negative regulation of RNA biosynthetic process] GO:1903011 [negative regulation of bone development] GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process] GO:1903611 [negative regulation of calcium-dependent ATPase activity] GO:1903625 [negative regulation of DNA catabolic process] GO:1903629 [positive regulation of dUTP diphosphatase activity] GO:1903634 [negative regulation of leucine-tRNA ligase activity] GO:2000279 [negative regulation of DNA biosynthetic process]
