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AKAP12

CANCER ATLAS

Gene description

 A kinase (PRKA) anchor protein 12

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006344
HPA056230
CAB026379

GENE INFORMATION

Gene name

 AKAP12 (HGNC Symbol)

Synonyms

 AKAP250, SSeCKS

Description

 A kinase (PRKA) anchor protein 12 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q25.1

Chromosome location (bp)

 151239999 - 151358557

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131016 (version 83.38)

Entrez gene

 9590

UniProt

 Q02952 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02952

Antibodypedia

 AKAP12 antibodies

PROTEIN BROWSER
AKAP12-001
AKAP12-002
AKAP12-201
AKAP12-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP12-001
ENSP00000253332
ENST00000253332
Q02952 [Direct mapping]
A-kinase anchor protein 12
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008179 [adenylate cyclase binding]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0051018 [protein kinase A binding]
GO:0090036 [regulation of protein kinase C signaling]
Show all
 1782 aa
191.5 kDa 		No 0
AKAP12-002
ENSP00000346702
ENST00000354675
Q02952 [Direct mapping]
A-kinase anchor protein 12
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008179 [adenylate cyclase binding]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0051018 [protein kinase A binding]
GO:0090036 [regulation of protein kinase C signaling]
Show all
 1684 aa
181.7 kDa 		No 0
AKAP12-201
ENSP00000352794
ENST00000359755
Q02952 [Direct mapping]
A-kinase anchor protein 12
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008179 [adenylate cyclase binding]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0051018 [protein kinase A binding]
GO:0090036 [regulation of protein kinase C signaling]
Show all
 1677 aa
181 kDa 		No 0
AKAP12-202
ENSP00000384537
ENST00000402676
Q02952 [Direct mapping]
A-kinase anchor protein 12
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008179 [adenylate cyclase binding]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0051018 [protein kinase A binding]
GO:0090036 [regulation of protein kinase C signaling]
Show all
 1782 aa
191.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.