Expression of EPS8L1 in cancer - Summary

CANCER ATLAS

Gene description

EPS8-like 1

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA041851	HPA043545

GENE INFORMATION
Gene name	EPS8L1 (HGNC Symbol)
Synonyms	DRC3, FLJ20258, MGC23164, MGC4642
Description	EPS8-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55072020 - 55087923
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131037 (version 83.38)
Entrez gene	54869
UniProt	Q8TE68 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE68
Antibodypedia	EPS8L1 antibodies

PROTEIN BROWSER

EPS8L1-001	EPS8L1-002	EPS8L1-004	EPS8L1-006	EPS8L1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPS8L1-001 ENSP00000201647 ENST00000201647	Q8TE68 [Direct mapping] Epidermal growth factor receptor kinase substrate 8-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0030676 [Rac guanyl-nucleotide exchange factor activity] GO:0032587 [ruffle membrane] GO:0035023 [regulation of Rho protein signal transduction] GO:0042608 [T cell receptor binding] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] GO:1900029 [positive regulation of ruffle assembly] Show all	723 aa 80.3 kDa	No	0
EPS8L1-002 ENSP00000466828 ENST00000586329	K7EN83 [Direct mapping] EPS8-like 1, isoform CRA_d; Epidermal growth factor receptor kinase substrate 8-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	548 aa 61.3 kDa	Yes	0
EPS8L1-004 ENSP00000437541 ENST00000540810	B4DKV7 [Direct mapping] Epidermal growth factor receptor kinase substrate 8-like protein 1; cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	659 aa 73.3 kDa	No	0
EPS8L1-006 ENSP00000245618 ENST00000245618	Q8TE68 [Direct mapping] Epidermal growth factor receptor kinase substrate 8-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0030676 [Rac guanyl-nucleotide exchange factor activity] GO:0032587 [ruffle membrane] GO:0035023 [regulation of Rho protein signal transduction] GO:0042608 [T cell receptor binding] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] GO:1900029 [positive regulation of ruffle assembly] Show all	596 aa 66.5 kDa	No	0
EPS8L1-007 ENSP00000466245 ENST00000588359	K7ELW3 [Direct mapping] Epidermal growth factor receptor kinase substrate 8-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	409 aa 46.1 kDa	No	0