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Cases of breast, ovarian, endometrial and thyroid cancers displayed moderate cytoplasmic positivity. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
DEFB118 (HGNC Symbol)
Synonyms
C20orf63, DEFB-18, dJ1018D12.3, ESC42
Description
Defensin, beta 118 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]
